Fractional-order differential model for knee implant recovery in smart health infrastructures

Chinebu, T. I., Okafor, K. C., Nwadinigwe, C. U., Nwigwe, J. O., Chidiebere, D. R., Okafor, I. P., Longe, O. M. and Anoh, K. (2026) Fractional-order differential model for knee implant recovery in smart health infrastructures. Scientific Reports. pp. 1-21. ISSN 2045-2322

[thumbnail of Chinebu, T.I., Okafor, K.C., Nwadinigwe, C.U. et al. Fractional-order differential model for knee implant recovery in smart health infrastructures. Sci Rep (2026). https://doi.org/10.1038/s41598-026-48965-7]
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Abstract

Recovery from knee replacement surgery in conventional orthopaedic healthcare systems can be delayed due to high costs, pain, limited monitoring, and insufficient follow-up, which may hinder early detection of poor healing and inflammation. This study presents a smart orthopaedic healthcare model for knee replacement recovery, where integrated sensors support continuous monitoring and improve the rehabilitation process, thereby reducing delays associated with traditional care systems. A mathematical modelling approach based on compartmental modelling and fractional-order dynamics is used to represent delayed healing responses following total knee replacement surgery. The analysis shows that prolonged delays in monitoring and treatment can lead to unstable recovery patterns, resulting in fluctuations in knee function and inflammation levels. To improve recovery outcomes, the study demonstrates that intelligent sensing devices providing real-time feedback effectively reduce inflammation and enhance joint performance. Results show that when delays are minimised, near-complete restoration of knee function is achieved (≥ 98%), accompanied by optimal inflammation suppression and functional recovery. However, in the presence of delays, recovery remains substantially improved, particularly in terms of inflammation control (≈ 92%), although overall functional gains and recovery efficiency are comparatively reduced. Overall, this work highlights the importance of early inflammation management and feedback-assisted rehabilitation in maintaining knee stability and accelerating recovery. The proposed model provides a theoretical foundation for developing advanced rehabilitation strategies and intelligent device-assisted therapies in smart orthopaedic healthcare systems.

Publication Type: Articles
Uncontrolled Keywords: artificial intelligence agents, computational model, fractional-order delay model, inflammation dynamics, IoT-enabled rehabilitation, patient-centred monitoring, post-surgical recovery
Subjects: Q Science > Q Science (General)
Q Science > QA Mathematics
Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QA Mathematics > QA76 Computer software
Q Science > QP Physiology
R Medicine > R Medicine (General)
T Technology > T Technology (General)
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Academic Areas > Department of Engineering, Computing and Design
Academic Areas > Department of Engineering, Computing and Design > Computing
Academic Areas > Department of Engineering, Computing and Design > Electrical Engineering
Academic Areas > Department of Engineering, Computing and Design > Mechanical Engineering
Academic Areas > Institute of Sport > Area > Sports Biomechanics and Sports Therapy
Academic Areas > Institute of Sport > Research Theme > Health and Well-Being
Academic Areas > School of Nursing and Allied Health
Academic Areas > School of Nursing and Allied Health > Nursing
Academic Areas > School of Nursing and Allied Health > Physiotherapy
Research Entities > Centre for Future Technologies
Research Entities > Centre for Health and Allied Sport and Exercise Science Research (CHASER)
Related URLs:
Depositing User: Kelvin Anoh
Date Deposited: 21 Apr 2026 13:50
Last Modified: 21 Apr 2026 13:50
URI: https://eprints.chi.ac.uk/id/eprint/8592

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