Fun with Cancer Patients: Practice-Based Research and the Affect of Cancer examines Fun with Cancer Patients, a project mixing strategies from live art, intervention performance and current discourses on performance documentation, to examine the personal experience of cancer. Fun with Cancer Patients was researched and developed through a Wellcome Trust Arts Award in 2010 and will be fully realised with a group of teenagers at Birmingham Children’s Hospital in association with Fierce Festival in 2013. This chapter demonstrates the strategies Fun with Cancer Patients takes to challenge all-inclusive narratives of an individual’s cancer experience and provide current cancer patients alternative modes of engagement, particularly for those who find the tools established for cancer patients to be limiting and/or reaffirming of a policed positivity. The chapter argues that Fun with Cancer Patients opens up new spaces for expression and works to capture a patient-focused experience inside of performance creation and subsequent exhibition. Employing theory on applied arts practice by Petra Kuppers and James Thompson, this chapter will demonstrate how Fun with Cancer Patients addresses existing tensions between applied arts projects and their public dissemination as a critical performance element.