The current study explores the occupational stressors and psychological well-being (PWB) of NHS nurses working on an Adult Rehabilitation ward at a local community hospital. The purpose of this study was to gain a deeper understanding of the perceived occupational stressors and PWB of nurses; with the potential implication for future additional support to all NHS nurses who need it. The qualitative research design of interviews with open-ended questions was used to explore the individualised perceptions of participating nurses. The qualitative analytic method of thematic analysis identified four emergent themes relating to the occupational stressors, challenges and PWB of nurses. It was found that nurses perceive a variety of different occupational stressors, with some participants expressing that any stressors identified do not have a personal impact. More strength in aspects of a nurses’ PWB were identified than weaknesses, concluding that nurses have a more positive outlook on their role regardless of the stressors they face.