Sustainable management of hospital waste requires an active involvement of all key players. We aim to test the hypothesis that three motivating factors, namely Reputation, Liability and Expense, influence hospital waste management. The survey for this study was conducted in two phases with the Pilot Study used for Exploratory Factor Analysis and the subsequent Main Study used for cross validation using Confirmatory Factor Analysis. The hypotheses were validated through one sample t tests. Correlations were established between the three motivating factors and organizational characteristics of hospital type, location, category and size. The hypotheses were validated and it was found that the factors of Liability and Expense varied considerably with respect to location and size of a hospital. The factor of Reputation, however, did not exhibit significant variation. In conclusion concerns about the reputation of a facility and an apprehension of liability act as incentives for sound hospital waste management whereas concerns about financial costs and perceived over-burden on staff act as disincentives.