Topical Imiquimod in primary Cutaneous Extramammary Paget’s Disease: a systematic review

Mayo-Martínez, F., Moro, R., Millán-Esteban, D., Ríos-Viñuela, E., Bautista, I. J., Nagore, E., Sanmartín, O. and Llombart, B. (2023) Topical Imiquimod in primary Cutaneous Extramammary Paget’s Disease: a systematic review. Cancers, 15 (23). pp. 1-16. ISSN 2072-6694

[thumbnail of © 2023 by the authors. Mayo-Martínez, F.; Moro, R. et al, Topical Imiquimod in Primary Cutaneous Extramammary Paget’s Disease: A Systematic Review. Cancers 2023, 15, 5665. https://doi.org/10.3390/]
Preview
Text (© 2023 by the authors. Mayo-Martínez, F.; Moro, R. et al, Topical Imiquimod in Primary Cutaneous Extramammary Paget’s Disease: A Systematic Review. Cancers 2023, 15, 5665. https://doi.org/10.3390/)
cancers-15-05665.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (1MB) | Preview
[thumbnail of © 2023 by the authors. Mayo-Martínez, F.; Moro, R. et al, Topical Imiquimod in Primary Cutaneous Extramammary Paget’s Disease: A Systematic Review. Cancers 2023, 15, 5665. https://doi.org/10.3390/] Archive (© 2023 by the authors. Mayo-Martínez, F.; Moro, R. et al, Topical Imiquimod in Primary Cutaneous Extramammary Paget’s Disease: A Systematic Review. Cancers 2023, 15, 5665. https://doi.org/10.3390/)
non-pdf-files.zip - Other
Available under License Creative Commons Attribution 4.0.

Download (655kB)

Abstract

Simple Summary: The main treatment for extramammary Paget’s disease (EMPD) is still surgery, but this neoplasm usually spreads beyond the clinical surroundings of the lesion, and achieving histopathologically free margins can be challenging and requires mutilating surgery. Moreover, the recurrence rate of the disease is high, reflecting its multifocal nature. Topical immunotherapy could be an alternative treatment for EMPD. The aim of this systematic review was to assess the effectiveness of topical imiquimod in the clinical response of EMPD patients and to describe the management of topical imiquimod in EMPD. Learning about non-surgical treatments such as topical imiquimod can help clinicians manage EMPD and find a balance between disease resolution and treatment morbidity. Abstract: Extramammary Paget’s disease (EMPD) is subclinical in extent and multifocal in nature. There is no global consensus for treatment, so its management represents a challenge in clinical practice. Therefore, we conducted a systematic review through the main electronic databases to assess the effectiveness of topical imiquimod in cutaneous EMPD and to discuss its management. Finally, 24 studies involving a total of 233 EMPD patients treated with topical imiquimod were selected. The topical imiquimod response rate was 67%, and the complete response (CR) rate was 48%. Patients were treated with a three–four times a week regimen in most cases, ranging between 2 to 52 weeks. In addition, imiquimod was applied as an adjunctive treatment in 21 patients, achieving a CR rate of 71%. Consequently, imiquimod therapy could achieve a good response ratio as a first-line treatment, as adjuvant and neo-adjuvant therapy, and as a treatment for recurrent disease. The heterogeneity between studies and the lack of a control arm made it impossible to conduct a meta-analysis. To improve the quality of evidence on EMPD, multicenter studies are essential to collect a larger number of patients and, consequently, obtain high-quality evidence to standardize treatment. The Prospero registration number is CRD42023447443.

Publication Type: Articles
Additional Information: Special Issue "Topical and Intralesional Immunotherapy for Skin Cancer" © 2023 by the authors
Uncontrolled Keywords: perianal Paget’s disease, imiquimod, scrotal Paget’s disease, vulvar Paget’s disease, extramammary Paget disease, extramammary Paget’s disease, topical immunotherapy, cutaneous Paget’s disease, treatment
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RD Surgery
R Medicine > RL Dermatology
Divisions: Academic Areas > Institute of Sport > Area > Sport and Exercise Psychology and Research Methods
Academic Areas > Institute of Sport > Research Theme > Enhancing Sport Performance
Research Entities > Centre for Health and Allied Sport and Exercise Science Research (CHASER)
SWORD Depositor: Publications Router Jisc
Depositing User: Publications Router Jisc
Date Deposited: 19 Feb 2024 11:34
Last Modified: 04 Jun 2024 09:31
URI: https://eprints.chi.ac.uk/id/eprint/7293

Actions (login required)

View Item
View Item
▲ Top

Our address

I’m looking for