In the early modern period Naples was a European centre of learning where a number of scholars engaged with alchemy. Variously perceived as a legitimate scientific practice or as a mendacious trick for gullible minds, alchemy engaged Neapolitan scholars in an ongoing dispute that involved members of the clergy. In this article I consider convents as research centres mainly engaged with medical alchemy. Specifically, I reconstruct the activity of the Dominican friar Tommaso d’Eremita. Upon his arrival at the Neapolitan convent of Santa Caterina a Formello in 1609, d’Eremita set up a laboratory where he spent years working on alchemical procedures in order to produce an elixir of life for the benefit of all. Beyond this charitable mission, I argue that members of religious orders in Naples engaged with alchemy for different purposes. In so doing, I discuss the cases of some members of religious orders in Naples who practised chrysopoeia with the aim of producing artificial noble metals.