This article examines the construction, the development and the denouement of the Museum of Safety in New York during the early twentieth century. Through a detailed assessment of the institution's own bulletin, newspapers and accompanying literature, the manner in which the museum served its visitors, promoted its cause and failed to secure its own future will be examined. The significance of this institution has been overlooked despite the way its role and responsibilities in exhibiting safety devices and procedures to industry, workers and the public reflect important trends within late nineteenth- and early twentieth-century society. The Museum of Safety also emerged as the effects of capitalism, immigration and industrialization began to be addressed. Examining the history of this “lost museum” will, therefore, reveal how responsibility, awareness and modernity were encountered in New York.