Singh, N., Hutson, R., Milton, N. G. N. and Javid, F. A. (2022) Ovarian cancer and KiSS-1 gene expression: A consideration of the use of Kisspeptin plus Kisspeptin aptamers in diagnostics and therapy. European journal of pharmacology, 917. p. 174752. ISSN 1879-0712
OvarianCancerAndKiSS1GeneExpressionAM-MILTON.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0.
Download (751kB) | Preview
Abstract
Gynaecological cancers continue to present a significant health burden upon the health of the global female population. This deficit is most prominent with ovarian cancer which possesses the lowest survival rate compared to all other cancers occurring within this anatomical region, with an annual UK-mortality of 7,300. The poor tolerability and selectively of the treatment options that are currently available is likely to have contributed to this high mortality rate thus, demonstrating the need for the development of enhanced therapeutic approaches. Aptamer technology would involve the engineering of specifically sequenced oligonucleotide chains, which bind to macromolecular targets with a high degree of affinity and selectively. Recent in-vitro studies conducted upon the clinical utility of this technique have supported its superiority in targeting individual therapeutic drug targets compared to various other targeting moieties currently within therapeutic use such as, monoclonal antibodies. For this reason, the employment of this technique is likely to be favourable in reducing the incidence of non-specific, chemotherapy-associated adverse effects. Kisspeptin is a naturally expressed polypeptide with an established role in the development of the reproductive system and other proposed roles in influencing the ability of ovarian cancer growths to exhibit the metastasis hallmark. This distinctive feature would indicate the potential for the manipulation of this pathway through the application of aptamer structures in developing a novel prophylactic strategy and improve the long-term outcome for ovarian cancer patients.
Publication Type: | Articles |
---|---|
Uncontrolled Keywords: | aptamer, oligonucleotide, ovarian cancer, anti-cancer, Kisspeptin, KISS |
Subjects: | R Medicine > RB Pathology R Medicine > RG Gynecology and obstetrics R Medicine > RM Therapeutics. Pharmacology |
Divisions: | Academic Areas > Institute of Sport Research Entities > Centre for Health and Allied Sport and Exercise Science Research (CHASER) |
Depositing User: | Nat Milton |
Date Deposited: | 16 Oct 2024 11:55 |
Last Modified: | 16 Oct 2024 11:55 |
URI: | https://eprints.chi.ac.uk/id/eprint/7794 |