Muscle carnosine concentration with the co-ingestion of carbohydrate with β-alanine in male rats

Naderi, A., Sadeghi, M., Sarshin, A., Imanipour, V., Nazeri, S., Farkhayi, F. and Willems, M. E. T. (2016) Muscle carnosine concentration with the co-ingestion of carbohydrate with β-alanine in male rats. Journal of Dietary Supplements, 14 (4). pp. 373-379. ISSN 1939-0211

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Muscle carnosine is an intracellular buffer. Intake of β-alanine combined with carbohydrate and protein enhanced carnosine loading in human muscle. The aim of the present study was to examine whether muscle carnosine loading was enhanced by β-alanine intake and co-ingestion of glucose in male rats. Thirty six male rats were divided into three groups and supplemented for 4 weeks: β-alanine (βA, 1.8% β-alanine in drinking water), β-alanine and glucose (βAGL, 1.8% β-alanine and 5% glucose in drinking water) and control (C, drinking water). During the supplementation period, rats were exercised (20 m·min-1, 10 min·day-1, 4 days·week-1 for 4 weeks). Muscle carnosine concentration was quantified in soleus (n=12) and rectus femoris (n=6) muscles using HPLC. In soleus muscle, carnosine concentration were 2.24±1.10, 6.12±1.08 and 6.93±2.56 mmol/kg dw for C, βA and βAGL. In rectus femoris, carnosine concentrations were 2.26±1.31, 7.90±1.66 and 8.59±2.33 mmol/kg dw for C, βA and βAGL, respectively. In each muscle, βA and βAGL resulted in similar carnosine increases compared to C. In conclusion, 4 weeks β-alanine intake, either alone or with glucose co-ingestion, equally increased muscle carnosine content. It appears that the potential insulin response to fluid glucose intake does not have an effect on muscle carnosine loading in male rats.

Publication Type: Articles
Uncontrolled Keywords: β-alanine, co-ingestion, carnosine, glucose, rats
Subjects: Q Science > Q Science (General)
Q Science > QP Physiology
Divisions: Academic Areas > Institute of Sport > Area > Exercise Physiology
Depositing User: Mark Willems
Date Deposited: 05 Oct 2016 14:41
Last Modified: 23 May 2019 14:55

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