Plasma uptake of selected phenolic acids following New Zealand blackcurrant extract supplementation in humans

Costello, Rianne, Keane, Karen, Lee, B. J., Willems, Mark E. T., Myers, Stephen D., Myers, Fiona, Lewis, Nathan A. and Blacker, Sam D. (2021) Plasma uptake of selected phenolic acids following New Zealand blackcurrant extract supplementation in humans. Journal of Dietary Supplements. pp. 1-16. ISSN 1939-0211

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New Zealand blackcurrant (NZBC) extract is a rich source of anthocyanins and in order to exert physiological effects, the anthocyanin-derived metabolites need to be bioavailable in vivo. We examined the plasma uptake of selected phenolic acids following NZBC extract supplementation alongside maintaining a habitual diet (i.e., not restricting habitual polyphenol intake). Twenty healthy volunteers (9 females, age: 28±7 years, height 1.73±0.09 m, body mass 73±11 kg) consumed a 300 mg NZBC extract capsule (CurraNZ™; anthocyanin content 105 mg) following an overnight fast. Venous blood samples were taken pre and 1, 1.5, 2, 3, 4, 5, and 6 h post-ingestion of the capsule. Plasma concentrations of vanillic acid (VA), gallic acid (GA), and protocatechuic acid (PCA) were analysed by reversed-phase high-performance liquid chromatography (HPLC) and the HPLC analysis identified two dihydroxybenzoic (VA and PCA) and one trihydroxybenzoic acids (GA) in plasma following NZBC extract supplementation. Habitual anthocyanin intake was 168 (95%CI:68–404) mg⋅day-1 and no associations were observed between this and VA, PCA, and GA plasma uptake by the NZBC extract intake. Plasma time-concentration curves revealed that GA, and PCA were most abundant at 4, and 1.5 h post-ingestion, representing a 261% and 320% increase above baseline, respectively, with VA remaining unchanged. This is the first study to demonstrate that an NZBC extract supplement increases the plasma uptake of phenolic acids GA, and PCA even when a habitual diet is followed in the days preceding the experimental trial, although inter-individual variability is apparent.

Item Type: Article
Additional Information: Deposited under the terms of the Creative Commons Attribution-NonCommercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.” Rianne Costello, Karen M. Keane, Ben J. Lee, Mark E. T. Willems, Stephen D. Myers, Fiona Myers, Nathan A. Lewis & Sam D. Blacker (2021) Plasma uptake of selected phenolic acids following New Zealand blackcurrant extract supplementation in humans, Journal of Dietary Supplements, DOI: 10.1080/19390211.2021.1914802
Uncontrolled Keywords: Acute-supplementation, anthocyanin, habitual diet, phenolic acids, systemic appearance
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Departments > Sport and Exercise Sciences
Depositing User: Mark Willems
Date Deposited: 08 Apr 2021 11:43
Last Modified: 28 May 2021 14:42

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