Serum neurofilament light concentration does not increase following exposure to low velocity football heading

Austin, Kieran, Lee, B. J., Flood, Tessa R., Toombs, Jamie, Borisova, Mina, Lauder, Mike A., Heslegrave, Amanda, Zetterberg, Henrik and Smith, Neal A. (2021) Serum neurofilament light concentration does not increase following exposure to low velocity football heading. Science and Medicine in Football, 5 (3). pp. 188-194. ISSN 2473-4446

[img] Text (This is an Accepted Manuscript of an article published by Taylor & Francis in Science and Medicine in Football on 01 December 2020, available online https://doi.org/10.1080/24733938.2020.1853210)
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Abstract

Objectives
To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills.

Methods
Forty-four males were randomized into either control (n=8), 10 header (n=12), 20 header (n=12) or 40 header (n=12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 hours, 24 hours and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform.

Results
Serum NF-L did not alter over time (p=0.44) and was not influenced by number of headers [p=0.47; mean(95% CI) concentrations at baseline 6.00 pg/ml (5.00 – 7.00 pg/ml); 6 hours post 6.50 pg/ml (5.70 – 7.29 pg/ml); 24 hours post 6.07 pg/ml (5.14 – 7.01 pg/ml); and 7 days post 6.46 pg/ml (5.45 – 7.46 pg/ml)]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations.

Conclusion
In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks.

Item Type: Article
Additional Information: Accepted author version posted online: 18 Nov 2020
Uncontrolled Keywords: Soccer, Heading, Brain Injury, Axonal Damage, Biomechanics
Subjects: G Geography. Anthropology. Recreation > GV Recreation Leisure > GV557 Sports
Q Science > QC Physics
Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Departments > Sport and Exercise Sciences
Depositing User: Neal Smith
Date Deposited: 20 Nov 2020 15:03
Last Modified: 26 Jul 2021 12:58
URI: http://eprints.chi.ac.uk/id/eprint/5484

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