Effects of blackcurrant extract on arterial functions in older adults: A randomized, double-blind, placebo-controlled, crossover trial

Okamoto, Takanobu, Hashimoto, Yuto, Kobayashi, Ryota, Nakazato, Koichi and Willems, Mark E. T. (2020) Effects of blackcurrant extract on arterial functions in older adults: A randomized, double-blind, placebo-controlled, crossover trial. Clinical and Experimental Hypertension, 42 (7). pp. 640-647. ISSN 1064-1963

[img] Text (This is an Accepted Manuscript of an article published by Taylor & Francis in Clinical and Experimental Hypertension; 42(7):640-647 on 12/05/2020, available online: http://www.tandfonline.com/10.1080/10641963.2020.1764015)
Okamoto et al 2020 Clin Exp Physiol.pdf - Accepted Version
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Purpose: Blackcurrant extract mainly contains anthocyanins. Several reports suggest that anthocyanins have beneficial effect for cardiovascular functions. The aim of this study was to examine the effect of 7-day intake of New Zealand blackcurrant (NZBC) extract on arterial functions, e.g. arterial stiffness, and serum lipids. Methods: A randomized, double-blind, placebo-controlled, crossover design study with a washout period of 28 days was conducted. Fourteen older adults participated in this study (age 73.3 ± 1.7 years). Participants took either a 7-day course of placebo or two capsules of NZBC extract (each 300 mg capsule contains 35% blackcurrant extract). Participants took one of the two trials first and then took the other after a washout period. Carotid-femoral pulse-wave velocity, an index of central arterial stiffness, and central blood pressure were measured at baseline and again at the end of the 7-day study period. Results: Compared to baseline, carotid-femoral pulse-wave velocity (P = 0.03) and central blood pressure (P = 0.02) decreased significantly after the 7-day study period with NZBC intake. In addition, carotid-femoral pulse-wave velocity (P = 0.04) and central blood pressure (P = 0.001) in the NZBC intake trial decreased significantly more than in the placebo intake trial. No effects were observed on serum lipids. Conclusion: These results suggest that short-term NZBC intake reduces central arterial stiffness and central blood pressure in older adults. Therefore, anthocyanin-rich blackcurrants might be beneficial for maintaining or improving cardiovascular health as an alternative to pharmaceutical medications.

Item Type: Article
Uncontrolled Keywords: Internal Medicine, Physiology, General Medicine, Anthocyanins; augmentation index; cardiovascular risk factors; pulse wave velocity; vascular function
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Research Centres > CCASES
Departments > Sport and Exercise Sciences
Depositing User: Mark Willems
Date Deposited: 24 Apr 2020 08:44
Last Modified: 30 Jun 2020 09:02
URI: http://eprints.chi.ac.uk/id/eprint/5139

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