Prolonged treadmill running in normobaric hypoxia causes gastrointestinal barrier permeability and elevates circulating levels of pro- and anti-inflammatory cytokines

Hill, G.W., Gillum, T.L., Lee, B. J., Romano, P.A., Schall, Z.J., Hamilton, A.M. and Kuennen, M.R. (2019) Prolonged treadmill running in normobaric hypoxia causes gastrointestinal barrier permeability and elevates circulating levels of pro- and anti-inflammatory cytokines. Applied Physiology Nutrition and Metabolism. ISSN 1715-5312

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Abstract

PURPOSE: This study examined the impact of treadmill running in normobaric hypoxia on gastrointestinal
barrier permeability and the systemic inflammatory response.

METHODS: Ten recreationally-active participants
completed two 1h bouts of matched-workload treadmill exercise(65% normoxic VO2max) in counterbalanced
order. One bout was performed in normoxia(NORM: FIO2=20.9%) and the other in normobaric hypoxia(HYP:
FIO2=13.5%). Minute ventilation(VE), respiratory rate(RR), tidal volume(VT), oxygen consumption(VO2), carbon
dioxide production(VCO2), respiratory quotient(RQ), and heart rate(HR) were measured with a metabolic cart.
Peripheral oxygen saturation(SpO2) was measured with pulse oximetry. Absolute tissue saturation(StO2) was
measured with near-infrared spectroscopy. Fatty acid-binding protein(I-FABP) and circulating cytokine
concentrations(IL-1Ra, IL-6, IL-10, TNFα) were assayed from plasma samples collected Pre, Post, 1h-Post, and
4h-Post exercise. Data were analyzed with 2-Way(Condition*Time) RM ANOVAs and Newman-Keuls post hocs
were run where appropriate(p<0.05).

RESULTS: As compared to NORM, 1h of treadmill exercise in HYP caused
greater(p<0.05) changes in VE(+30%), RR(+16%), VT(+10%), VCO2(+18%), RQ(+16%), HR(+4%), SpO2(-16%)
and StO2(-10%). Gut barrier permeability and circulating cytokine concentrations were also greater(p<0.05)
following HYP exercise, where I-FABP was shown increased at Post(+68%) and IL-1Ra at 1h-Post(+266%). IFABP and IL-1Ra did not change following NORM exercise. IL-6 and IL-10 increased with exercise in both
study conditions but were increased more(p<0.05) following HYP exercise at Post(+705% and +127%;
respectively) and 1h-Post(+400% and +128%; respectively).

KEY FINDINGS:
Normobaric hypoxia caused significant desaturation and increased most cardiopulmonary responses by 10-30%. Significant gut barrier permeability and increased pro- and anti-inflammatory cytokine concentrations could promote an "open window" in the hours following HYP exercise.

Item Type: Article
Uncontrolled Keywords: altitude training, endurance exercise, cardiopulmonary response, gastrointestinal barrier, inflammation, exercise immunology, Nutrition and Dietetics, Physiology (medical), Physiology, Endocrinology, Diabetes and Metabolism, General Medicine
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Departments > Sport and Exercise Sciences
Related URLs:
Depositing User: Angela Roberts
Date Deposited: 25 Oct 2019 12:19
Last Modified: 25 Oct 2019 14:09
URI: http://eprints.chi.ac.uk/id/eprint/4917

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