Neural activity during the viewing of emotional pictures in veterans with pathological anger and aggression

Heesink, L., Gladwin, Thomas Edward, Vink, M., van Honk, J., Kleber, R. and Geuze, E. (2017) Neural activity during the viewing of emotional pictures in veterans with pathological anger and aggression. European psychiatry: the journal of the Association of European Psychiatrists, 47. pp. 1-8. ISSN 0924-9338

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Abstract

Anger and aggression are common mental health problems after military deployment. Anger and aggression have been associated with abnormalities in subcortical and cortical levels of the brain and their connectivity. Here, we tested brain activation during the processing of emotional stimuli in military veterans with and without anger and aggression problems. Thirty military veterans with anger and aggression problems and 29 veterans without a psychiatric diagnosis (all males) participated in this study. During an fMRI scan 32 negative, 32 positive and 32 neutral pictures from the International Affective Picture System were presented in intermixed order. The Aggression group showed heightened activity in brain areas including the supplementary motor area, the cingulum and the parietal cortex, in response to stimuli, regardless of category. Furthermore, the Aggression group showed stronger connectivity between the dorsal anterior cingulate cortex (dACC) and the amygdala during the viewing of negative stimuli, and weaker connectivity between dACC and medial prefrontal cortex during the viewing of positive stimuli. Veterans with anger and aggression problems showed enhanced brain response to all stimuli during the task, irrespective of valence and they rated the pictures more likely as negative. We take this to indicate enhanced preparation for action and attention to the presentation of stimuli that could prove to be threatening. Further, group differences in functional connectivity involving the dACC reveal abnormal processing of stimuli with negative and positive valence. In sum, the results point towards a bias towards an enhanced sensitivity to perceived or potential threat in aggression. [Abstract copyright: Copyright © 2017 Elsevier Masson SAS. All rights reserved.]

Item Type: Article
Additional Information: ** From PubMed via Jisc Publications Router. ** History: received 05-05-2017; revised 15-08-2017; accepted 05-09-2017.
Uncontrolled Keywords: Aggression, Anger, Attention, Emotional stimuli, Functional connectivity, fMRI
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
U Military Science > U Military Science (General)
Divisions: Departments > Psychology and Counselling
Related URLs:
SWORD Depositor: Debbie Bogard
Depositing User: Debbie Bogard
Date Deposited: 05 Apr 2018 15:52
Last Modified: 22 Sep 2018 00:10
URI: http://eprints.chi.ac.uk/id/eprint/3124

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